Viral Dynamic Model of Antiretroviral Therapy Including the Integrase Inhibitor Raltegravir in Patients with HIV-1

Dimitra Bon, Christoph Stephan, Oliver Keppler, Eva Herrmann

Abstract


Antiviral combination therapies consisting of reverse transcriptase inhibitors, protease inhibitors and an integrase inhibitor, have been developed to suppress HIV below the limit of detection.

We introduce a mathematical model for the effect of different combination treatment regimens on the dynamics of HIV RNA and CD4 T-cell counts. We will especially focus on modelling the treatment effect of the integrase inhibitor-Raltegravir. The model consists of a system of ordinary differential equations and the parameters were chosen or estimated in order to agree with clinical data of a recent clinical trial. All the numerical simulations were calculated with Matlab.


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DOI: http://dx.doi.org/10.11145/j.biomath.2012.09.251

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ISSN 1314-7218 (online)
ISSNĀ 1314-684X (print)

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