Modeling of Viral Dynamics after Liver Transplantation in Patients with Chronic Hepatitis B and D

Natalie Filmann, Eva Herrmann

Abstract


Viral kinetic models have become an important tool for understanding the main biological processes behind the dynamics of chronic viral diseases and optimizing effectiveness of anti-viral therapy. We analyzed the dynamics of hepatitis B and D co-infection (HBV/HDV) and the pharmacokinetics/pharmacodynamics of the reinfection prophylaxis with polyclonal antibodies after liver transplantation. Therefore we developed a mechanistic model consisting of a system of ordinary differential equations. This model was fitted by analyzing the kinetics of HBV/HDV viremia after liver transplantation in patient data and correlated with the reinfection prophylaxis dosing schemes. The results suggest that this modeling approach may help to optimize reinfection prophylaxis.

Keywords


Infectious diseases; hepatitis B and D; viral dynamics; PK/PD

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DOI: http://dx.doi.org/10.11145/j.biomath.2012.09.022

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